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Research on Anti Aging ingredients

250 mg – Magnesium

Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis. - Imperial College London (American Journal of Cinical Nutrition)
Dietary magnesium and calcium intake and risk of depression in the general population: A meta-analysis. -- Aust N Z J Psychiatry Qingdao University (China)
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. -- Journal of Nutrition -- Tufts University

250mg – Calcium

Lower serum calcium is independently associated with chronic kidney disease progression -- Sci Rep. 2018 -- Leiden University Medical Center, The Netherlands
Calcium and magnesium can lessen the incidence of oxaliplatin induced neuropathy. -- Shanghai Institute of Digestive Disease
Calcium supplementation has beneficial effect on blood lipids - J Cardiovasc Nurs. 2016 - Xuzhou Medical University,and Johns Hopkins University,

100mg – CoQ10

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. -- Arch Neurol. -- Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
Open label trial of coenzyme Q10 as a migraine preventive. -- Cephalalgia. 2002 -- Thomas Jefferson University
Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. -- Pharmacol Res. 2017 -- Department of Nutrition and Food Hygiene, Soochow University (China)

15mg – Vitamin B1

The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. -- J Am Coll Cardiol St. Michael's Hospital, Toronto
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. -- Case Rep Neurol Med. 2018 -- Università Cattolica di Roma
Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. -- Cancer Causes Control. 2003 -- University of Hawaii

15mg – Vitamin B2

The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising -- Med Chem. 2017 -- Victoria University, Australia
Moderate consumption of riboflavin may be protective against postpartum depression -- Cancer Lett. -- Fukuoka University, Japan
Vitamin B2 intake and the risk of colorectal cancer: a meta-analysis of observational studies. -- Asian Pac J Cancer Prev. 2015 -- Shantou University Medical College

3.2mg – Vitamin B3

Niacin modulates macrophage polarization in Parkinson's disease. --J Neuroimmunol. 2018 -- Medical College of Georgia, Augusta University
Niacin treatment improves endothelial dysfunction in patients with Coronary Artery Disease. -- Atherosclerosis. 2009 -- Johannes Gutenberg-University , Germany
Niacin promotes cardiac healing after myocardial infarction. -- J Pharmacol Exp Ther. 2017 -- Vanderbilt University Medical Center

25mg – Pantothenic acid

Higher vitamin B5 intake was significantly related to lower or attenuated increase in c-reactive protein concentration -- Hanyang University, South Korea
Radiation-induced antitumor properties of vitamin B5 (pantothenic acid) and its effect on mitomycin C activity: experiments in vitro. -- Oncol Res. 2007 -- University of Vienna

15mg – Vitamin B6

Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. -- Neurology. 2006 -- Erasmus Medical Center, The Netherlands
Folic aicd combined with vitamin B6 and B12 treatment significantly reduced plasma homocysteine level -- Taizhou Hospital of Zhejiang Province (China)
Low levels of vitamin b-6 are associated with gastritis and gastric cancer - Gut J

400mcg – Folic Acid

Dietary folate is inversely associated with the risk of esophageal squamous-cell carcinoma -- Ann Oncol. 2006 -- Istituto di Ricerche Farmacologiche , Italy
Combined treatment with folic acid, vitamin B6, and vitamin B12 lowers homocysteine concentrations. -- J Am Heart Assoc. 2018 -- Harvard Medical School

6mcg – Biotin

Biotin has therapeutic value in the treatment of brittle nails -- Columbia University
Chromium/biotin supplementation improves glycemic control in patients with type 2 diabetes mellitus -- Diabetes Technol Ther. 2006 -- Yale University School of Medicine

500mcg – Vitamin B12

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial.-- Int J Geriatr Psychiatry. 2011 -- University of Oxford
Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases. -- J Geriatr Psychiatry Neurol. 2017 -- Fujian Medical University (China)
Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. -- Cancer Epidemiol Biomarkers Prev. -- University of Arizona

500mg Vitamin C

Vitamin C shows promise as brain aging treatment Konkuk University (S Korea), January 18 2019.
Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies. -- Br J Nutr. 2018
Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials. -- Tianjin Academy of Integrative Medicine (China)
A Meta-analysis of Randomized Control Trials: the Impact of Vitamin C Supplementation on Serum CRP and serum hs-CRP Concentrations. -- University of Newcastle (Australia)

200mg Vitamin E (natural)

Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies. -- Int J Geriatr Psychiatry. 2017 -- Center for Disease Control and Prevention,China.
A deficiency in circulating total tocopherols might be associated with higher coronary artery disease risk. -- Eur J Prev Cardiol. 2015 -- China Medical University, China.
A high level of vitamin E might be a protective factor for populations at risk for pancreatic cancer. -- Med Sci Monit. 2015 -- Third Military Medical University, China

250mg L-Carnosine

Synergistic effect of L-Carnosine and EGCG in prevention of physiological brain aging. -- Curr Pharm Des. 2012 -- Synergistic effect of L-Carnosine and EGCG in prevention of physiological brain aging.
Carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. -- Chungshan Medical University Hospital, Taiwan

20mg NADH

Nicotinamide adenine dinucleotide (NADH) compares favorably to conventional therapy for chronic fatigue syndrome -- University of Puerto Rico School of Medicine
Nicotinamide mononucleotide protects againstß-amyloid oligomer - induced cognitive impairment and neuronal death -- Brain Res. 2016 -- National Center for Geriatrics and Gerontology, Japan
Nicotinamide adenine dinucleotide (NADH) relieves anxiety and reduces heart rate in patients with chronic fatigue syndrome -- Rev Clin Esp. 2010 -- Hospital Vall d'Hebrón (Spain)

10mg. PPQ

PQQ supplementation enhanced mitochondria related functions -- J Nutr Biochem. 2013 -- University of California, Davis
Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. -- Biochem Biophys Res Commun. 2007
Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. -- Cardiovasc Drugs Ther. 2004

20mg. Pine Bark Extract 95%

Pcynogenol has protective effects on kidney flow and function in hypertension and reduces C-reactive protein. -- D'Annunzio University,Italy.
This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on blood pressure -- Soochow University, China.
Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). -- J Inflamm (Lond). 2006 -- Julius-Maximilians-Universität, Germany

200mg. Turmeric Extract 95%

Curcumin for Cognitive Function in Aging Adults -- UCLA Longevity Center, February 5, 2019
Curcumin may help mitigate metabolic and oxidative alterations caused by hormone deprivation in events such as menopause -- Federal University of Rio Grande do Sul (Brazil), 06-Jan-2019
Compelling study confirms the therapeutic effects of curcumin in removing fluoride from our bodies --
Mohanlal Sukhadia University (India), November 26, 2018
Curcumin downregulates human tumor necrosis factor-a levels: A systematic review and meta-analysis ofrandomized controlled trials. -- Pharmacol Res. 2016 -- University of Western Australia

100mg Resveratrol

Effects of resveratrol on pancreatic cancer cell proliferation -- University of Arkansas, 11-30-18
This meta analysis confirmed the potential of resveratrol against lung carcinogenesis. -- Guangxi Traditional Chinese Medicine University
Dietary grape supplementation may play a role in colon cancer prevention for high-risk individuals. -- Nutr J. 2015 -- Icahn School of Medicine at Mount Sinai
An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. -- Am J Clin Nutr. 2010 -- Biosciences, Zeist, The Netherlands