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Research on Anti Aging ingredients

250 mg – Magnesium

  • Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis.  - Imperial College London (American Journal of Cinical Nutrition)
  • Dietary magnesium and calcium intake and risk of depression in the general population: A meta-analysis. --  Aust N Z J Psychiatry   Qingdao University (China)
  • Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. -- Journal of Nutrition -- Tufts University

250mg – Calcium

  • Lower serum calcium is independently associated with chronic kidney disease progression -- Sci Rep. 2018 -- Leiden University Medical Center, The Netherlands
  • Calcium and magnesium can lessen the incidence of oxaliplatin induced neuropathy. -- Shanghai Institute of Digestive Disease
  • Calcium supplementation has beneficial effect on blood lipids -  J Cardiovasc Nurs. 2016 - Xuzhou Medical University,and  Johns Hopkins University,

100mg – CoQ10

  • Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. --  Arch Neurol. -- Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.
  • Open label trial of coenzyme Q10 as a migraine preventive. --  Cephalalgia. 2002  -- Thomas Jefferson University
  • Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. --  Pharmacol Res. 2017 --  Department of Nutrition and Food Hygiene, Soochow University (China)

15mg – Vitamin B1

  • The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. -- J Am Coll Cardiol    St. Michael's Hospital, Toronto
  • Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. --  Case Rep Neurol Med. 2018  --  Università Cattolica di Roma
  • Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. -- Cancer Causes Control. 2003 -- University of Hawaii

15mg – Vitamin B2

  • The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising -- Med Chem. 2017 -- Victoria University, Australia
  • Moderate consumption of riboflavin may be protective against postpartum depression -- Cancer Lett. -- Fukuoka University, Japan
  • Vitamin B2 intake and the risk of colorectal cancer: a meta-analysis of observational studies. --  Asian Pac J Cancer Prev. 2015 -- Shantou University Medical College

3.2mg – Vitamin B3

  • Niacin modulates macrophage polarization in Parkinson's disease. --J Neuroimmunol. 2018  --  Medical College of Georgia, Augusta University
  • Niacin treatment improves endothelial dysfunction in patients with Coronary Artery Disease. -- Atherosclerosis. 2009 -- Johannes Gutenberg-University , Germany
  • Niacin promotes cardiac healing after myocardial infarction. --  J Pharmacol Exp Ther. 2017 -- Vanderbilt University Medical Center

25mg – Pantothenic acid

  • Higher vitamin B5 intake was significantly related to lower or attenuated increase in c-reactive protein concentration -- Hanyang University, South Korea
  • Radiation-induced antitumor properties of vitamin B5 (pantothenic acid) and its effect on mitomycin C activity: experiments in vitro. --  Oncol Res. 2007 --  University of Vienna

15mg – Vitamin B6

  • Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease. -- Neurology. 2006 -- Erasmus Medical Center, The Netherlands
  • Folic aicd combined with vitamin B6 and B12 treatment significantly reduced plasma homocysteine level -- Taizhou Hospital of Zhejiang Province (China)
  • Low levels of vitamin b-6 are associated with gastritis and gastric cancer - Gut J 

400mcg – Folic Acid 

  • Dietary folate is inversely associated with the risk of esophageal squamous-cell carcinoma -- Ann Oncol. 2006  -- Istituto di Ricerche Farmacologiche , Italy
  • Combined treatment with folic acid, vitamin B6, and vitamin B12 lowers homocysteine concentrations. -- J Am Heart Assoc. 2018  -- Harvard Medical School

6mcg – Biotin 

  • Biotin has therapeutic value in the treatment of brittle nails -- Columbia University
  • Chromium/biotin supplementation improves glycemic control in patients with type 2 diabetes mellitus -- Diabetes Technol Ther. 2006 -- Yale University School of Medicine

500mcg – Vitamin B12

  • Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial.--  Int J Geriatr Psychiatry. 2011 -- University of Oxford
  • Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases. -- J Geriatr Psychiatry Neurol. 2017  -- Fujian Medical University (China)
  • Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. -- Cancer Epidemiol Biomarkers Prev. -- University of Arizona

500mg Vitamin C

  • Vitamin C shows promise as brain aging treatment   Konkuk University (S Korea), January 18 2019. 
  • Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies.   --  Br J Nutr. 2018
  • Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials.  -- Tianjin Academy of Integrative Medicine (China)
  • A Meta-analysis of Randomized Control Trials: the Impact of Vitamin C Supplementation on Serum CRP and serum hs-CRP Concentrations.  -- University of Newcastle (Australia)

200mg Vitamin E (natural)

  • Do low-serum vitamin E levels increase the risk of Alzheimer disease in older people? Evidence from a meta-analysis of case-control studies. --  Int J Geriatr Psychiatry. 2017 -- Center for Disease Control and Prevention,China.
  • A deficiency in circulating total tocopherols might be associated with higher coronary artery disease risk. --  Eur J Prev Cardiol. 2015 -- China Medical University, China.
  • A high level of vitamin E might be a protective factor for populations at risk for pancreatic cancer. -- Med Sci Monit. 2015 -- Third Military Medical University, China

250mg L-Carnosine

  • Synergistic effect of L-Carnosine and EGCG in prevention of physiological brain aging. --  Curr Pharm Des. 2012  -- Synergistic effect of L-Carnosine and EGCG in prevention of physiological brain aging.
  • Carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation.  --  Chungshan Medical University Hospital, Taiwan

20mg  NADH

  • Nicotinamide adenine dinucleotide (NADH) compares favorably to conventional therapy for chronic fatigue syndrome --  University of Puerto Rico School of Medicine
  • Nicotinamide mononucleotide protects againstß-amyloid oligomer - induced cognitive impairment and neuronal death -- Brain Res. 2016 -- National Center for Geriatrics and Gerontology, Japan
  • Nicotinamide adenine dinucleotide (NADH) relieves anxiety and reduces heart rate in patients with chronic fatigue syndrome -- Rev Clin Esp. 2010 -- Hospital Vall d'Hebrón (Spain)

10mg. PPQ

  • PQQ supplementation enhanced mitochondria related functions --  J Nutr Biochem. 2013 -- University of California, Davis
  • Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. --  Biochem Biophys Res Commun. 2007
  • Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. --  Cardiovasc Drugs Ther. 2004 

20mg. Pine Bark Extract 95%

  • Pcynogenol has protective effects on kidney flow and function in hypertension and reduces C-reactive protein. -- D'Annunzio University,Italy.
  • This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on blood pressure -- Soochow University, China.
  • Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). --  J Inflamm (Lond). 2006 -- Julius-Maximilians-Universität, Germany

200mg. Turmeric Extract 95%

  • Curcumin for Cognitive Function in Aging Adults --  UCLA Longevity Center, February 5, 2019
  • Curcumin may help mitigate metabolic and oxidative alterations caused by hormone deprivation in events such as menopause -- Federal University of Rio Grande do Sul (Brazil), 06-Jan-2019
  • Compelling study confirms the therapeutic effects of curcumin in removing fluoride from our bodies -- 
  • Mohanlal Sukhadia University (India), November 26, 2018
  • Curcumin downregulates human tumor necrosis factor-a levels: A systematic review and meta-analysis ofrandomized controlled trials. --  Pharmacol Res. 2016  -- University of Western Australia

100mg Resveratrol

  • Effects of resveratrol on  pancreatic cancer cell proliferation -- University of Arkansas, 11-30-18
  • This meta analysis confirmed the potential of resveratrol against lung carcinogenesis. -- Guangxi Traditional Chinese Medicine University
  • Dietary grape supplementation may play a role in colon cancer prevention for high-risk individuals. -- Nutr J. 2015 -- Icahn School of Medicine at Mount Sinai
  • An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. --  Am J Clin Nutr. 2010 --  Biosciences, Zeist, The Netherlands
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